H2N2V1, 1957, Analysis, bibRecord, 000054

Significant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010

Identifieur interne : 000054 ( 1957/Analysis ); précédent : 000053; suivant : 000055

Significant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010

Auteurs : Ritsuko Kubota-Koketsu ; Mikihiro Yunoki [Japon] ; Yoshinobu Okuno ; Kazuyoshi Ikuta

Source :

Biologics : Targets & Therapy [ 1177-5475 ] ; 2012.

RBID : PMC:3413397

Abstract

Influenza A H2N2 virus, also known as the Asian flu, spread worldwide from 1957 to 1967, although there have been no cases reported in humans in the past 40 years. A vaccination program was introduced in Japan in the 1960s. Older Japanese donors could have been naturally infected with the H2N2 virus or vaccinated in the early 1960s. Human intravenous immunoglobulin (IVIG) reflects the epidemiological status of the donating population in a given time period. Here, the possible viral neutralizing (VN) activities of IVIG against the H2N2 virus were examined. Hemagglutination inhibition (HI) and VN activities of IVIG lots manufactured from 1993 to 2010 in Japan and the United States were evaluated against H2N2 viruses. High HI and VN activities against H2N2 viruses were found in all the IVIG lots investigated. HI titers were 32–64 against the isolate in 1957 and 64–128 against the isolates in 1965. VN titers were 80–320 against the isolate in 1957 and 1280–5120 against the isolates in 1965. Both the HI and VN titers were higher against the isolate in 1965 than in 1957. Thus, antibody titers of IVIG against influenza viruses are well correlated with the history of infection and the vaccine program in Japan. Therefore, evaluation of antibody titers provides valuable information about IVIGs, which could be used for immune stimulation when a new influenza virus emerges in the human population.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413397

DOI: 10.2147/BTT.S33495
PubMed: 22888217
PubMed Central: 3413397

Affiliations:

Japon

Links to Exploration step

PMC:3413397

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Significant neutralizing activities against H2N2 influenza A viruses
in human intravenous immunoglobulin lots manufactured from 1993 to
2010</title>
<author><name sortKey="Kubota Koketsu, Ritsuko" sort="Kubota Koketsu, Ritsuko" uniqKey="Kubota Koketsu R" first="Ritsuko" last="Kubota-Koketsu">Ritsuko Kubota-Koketsu</name>
<affiliation><nlm:aff id="af1-btt-6-245">Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, Kagawa;</nlm:aff>
<wicri:noCountry code="subfield">Kagawa</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yunoki, Mikihiro" sort="Yunoki, Mikihiro" uniqKey="Yunoki M" first="Mikihiro" last="Yunoki">Mikihiro Yunoki</name>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-btt-6-245">Pathogenic Risk Management, Benesis Corporation, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Pathogenic Risk Management, Benesis Corporation, Osaka</wicri:regionArea>
<wicri:noRegion>Osaka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name>
<affiliation><nlm:aff id="af1-btt-6-245">Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, Kagawa;</nlm:aff>
<wicri:noCountry code="subfield">Kagawa</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ikuta, Kazuyoshi" sort="Ikuta, Kazuyoshi" uniqKey="Ikuta K" first="Kazuyoshi" last="Ikuta">Kazuyoshi Ikuta</name>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22888217</idno>
<idno type="pmc">3413397</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413397</idno>
<idno type="RBID">PMC:3413397</idno>
<idno type="doi">10.2147/BTT.S33495</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">000921</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000921</idno>
<idno type="wicri:Area/Pmc/Curation">000921</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000921</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000681</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000681</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:22888217</idno>
<idno type="wicri:Area/PubMed/Corpus">000137</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000137</idno>
<idno type="wicri:Area/PubMed/Curation">000137</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000137</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000124</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000124</idno>
<idno type="wicri:Area/Ncbi/Merge">000802</idno>
<idno type="wicri:Area/Ncbi/Curation">000802</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000802</idno>
<idno type="wicri:doubleKey">1177-5475:2012:Kubota Koketsu R:significant:neutralizing:activities</idno>
<idno type="wicri:Area/Main/Merge">000A15</idno>
<idno type="wicri:Area/Main/Curation">000A15</idno>
<idno type="wicri:Area/Main/Exploration">000A15</idno>
<idno type="wicri:Area/1957/Extraction">000054</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Significant neutralizing activities against H2N2 influenza A viruses
in human intravenous immunoglobulin lots manufactured from 1993 to
2010</title>
<author><name sortKey="Kubota Koketsu, Ritsuko" sort="Kubota Koketsu, Ritsuko" uniqKey="Kubota Koketsu R" first="Ritsuko" last="Kubota-Koketsu">Ritsuko Kubota-Koketsu</name>
<affiliation><nlm:aff id="af1-btt-6-245">Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, Kagawa;</nlm:aff>
<wicri:noCountry code="subfield">Kagawa</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Yunoki, Mikihiro" sort="Yunoki, Mikihiro" uniqKey="Yunoki M" first="Mikihiro" last="Yunoki">Mikihiro Yunoki</name>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-btt-6-245">Pathogenic Risk Management, Benesis Corporation, Osaka, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Pathogenic Risk Management, Benesis Corporation, Osaka</wicri:regionArea>
<wicri:noRegion>Osaka</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name>
<affiliation><nlm:aff id="af1-btt-6-245">Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, Kagawa;</nlm:aff>
<wicri:noCountry code="subfield">Kagawa</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ikuta, Kazuyoshi" sort="Ikuta, Kazuyoshi" uniqKey="Ikuta K" first="Kazuyoshi" last="Ikuta">Kazuyoshi Ikuta</name>
<affiliation><nlm:aff id="af2-btt-6-245">Department of Virology, Research Institute for Microbial Diseases, Osaka University</nlm:aff>
<wicri:noCountry code="subfield">Osaka University</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Biologics : Targets & Therapy</title>
<idno type="ISSN">1177-5475</idno>
<idno type="eISSN">1177-5491</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Influenza A H2N2 virus, also known as the Asian flu, spread worldwide from 1957
to 1967, although there have been no cases reported in humans in the past 40
years. A vaccination program was introduced in Japan in the 1960s. Older
Japanese donors could have been naturally infected with the H2N2 virus or
vaccinated in the early 1960s. Human intravenous immunoglobulin (IVIG) reflects
the epidemiological status of the donating population in a given time period.
Here, the possible viral neutralizing (VN) activities of IVIG against the H2N2
virus were examined. Hemagglutination inhibition (HI) and VN activities of IVIG
lots manufactured from 1993 to 2010 in Japan and the United States were
evaluated against H2N2 viruses. High HI and VN activities against H2N2 viruses
were found in all the IVIG lots investigated. HI titers were 32–64
against the isolate in 1957 and 64–128 against the isolates in 1965. VN
titers were 80–320 against the isolate in 1957 and 1280–5120
against the isolates in 1965. Both the HI and VN titers were higher against the
isolate in 1965 than in 1957. Thus, antibody titers of IVIG against influenza
viruses are well correlated with the history of infection and the vaccine
program in Japan. Therefore, evaluation of antibody titers provides valuable
information about IVIGs, which could be used for immune stimulation when a new
influenza virus emerges in the human population.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Hirota, Y" uniqKey="Hirota Y">Y Hirota</name>
</author>
<author><name sortKey="Kaji, M" uniqKey="Kaji M">M Kaji</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, W" uniqKey="Ma W">W Ma</name>
</author>
<author><name sortKey="Vincent, Al" uniqKey="Vincent A">AL Vincent</name>
</author>
<author><name sortKey="Gramer, Mr" uniqKey="Gramer M">MR Gramer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yunoki, M" uniqKey="Yunoki M">M Yunoki</name>
</author>
<author><name sortKey="Kubota Koketsu, R" uniqKey="Kubota Koketsu R">R Kubota-Koketsu</name>
</author>
<author><name sortKey="Urayama, T" uniqKey="Urayama T">T Urayama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Okuno, Y" uniqKey="Okuno Y">Y Okuno</name>
</author>
<author><name sortKey="Tanaka, K" uniqKey="Tanaka K">K Tanaka</name>
</author>
<author><name sortKey="Baba, K" uniqKey="Baba K">K Baba</name>
</author>
<author><name sortKey="Maeda, A" uniqKey="Maeda A">A Maeda</name>
</author>
<author><name sortKey="Kunita, N" uniqKey="Kunita N">N Kunita</name>
</author>
<author><name sortKey="Ueda, S" uniqKey="Ueda S">S Ueda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nabel, Gj" uniqKey="Nabel G">GJ Nabel</name>
</author>
<author><name sortKey="Wei, Cj" uniqKey="Wei C">CJ Wei</name>
</author>
<author><name sortKey="Ledgerwood, Je" uniqKey="Ledgerwood J">JE Ledgerwood</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Japon</li>
</country>
</list>
<tree><noCountry><name sortKey="Ikuta, Kazuyoshi" sort="Ikuta, Kazuyoshi" uniqKey="Ikuta K" first="Kazuyoshi" last="Ikuta">Kazuyoshi Ikuta</name>
<name sortKey="Kubota Koketsu, Ritsuko" sort="Kubota Koketsu, Ritsuko" uniqKey="Kubota Koketsu R" first="Ritsuko" last="Kubota-Koketsu">Ritsuko Kubota-Koketsu</name>
<name sortKey="Okuno, Yoshinobu" sort="Okuno, Yoshinobu" uniqKey="Okuno Y" first="Yoshinobu" last="Okuno">Yoshinobu Okuno</name>
</noCountry>
<country name="Japon"><noRegion><name sortKey="Yunoki, Mikihiro" sort="Yunoki, Mikihiro" uniqKey="Yunoki M" first="Mikihiro" last="Yunoki">Mikihiro Yunoki</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/1957/Analysis

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000054 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd -nk 000054 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    1957
   |étape=   Analysis
   |type=    RBID
   |clé=     PMC:3413397
   |texte=   Significant neutralizing activities against H2N2 influenza A viruses
in human intravenous immunoglobulin lots manufactured from 1993 to
2010
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/1957/Analysis/RBID.i   -Sk "pubmed:22888217" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/1957/Analysis/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

Significant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010

Significant neutralizing activities against H2N2 influenza A viruses in human intravenous immunoglobulin lots manufactured from 1993 to 2010

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.